Virtual Tissue Models in Developmental Toxicity Research

Courtesy Recent Science Inventory records from the EPA  Tue, 07/07/2009 - 13:45

Prenatal exposure to drugs and chemicals may perturb, directly or indirectly, core developmental processes in the embryo (patterning, morphogenesis, proliferation and apoptosis, and cell differentiation), leading to adverse developmental outcomes.

Because embryogenesis entails a genomic program that orchestrates aggregate cell behaviors across time and space, a challenge for systems biology is to integrate data and knowledge from the genomic sciences into multi-scale models of developmental toxicity that can be translated into a regulatory context.

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