Use of Toxicogenomic Data at the US EPA to Inform the Cancer Ase...

Courtesy Recent Science Inventory records from the EPA  Thu, 07/09/2009 - 13:04

The Office of Pesticide Programs? (OPP) routinely utilizes mode of action (MOA) data when available for pesticide cancer risk assessment.

A MOA analysis incorporates data from required toxicology studies and supplemental mechanistic data. These data are evaluated to identify a set of key events, quantifiable and critical steps, in the pathway to tumor development.

The U. S. EPA has considered genomic data as part of the weight-of-the-evidence (WOE) in support of a MOA.

However, to expand this effort, standard approaches...

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