Toxicogenomic Effects Common to Triazole Antifungals and Conserv...

Courtesy Recent Science Inventory records from the EPA  Fri, 07/31/2009 - 12:00

The triazole antifungals myclobutanil, propiconazole and triadimefon cause varying degrees of hepatic toxicity and disrupt steroid hormone homeostasis in rodent in vivo models.

To identify biological pathways consistently modulated across multiple time-points and various study designs, gene expression profiling was conducted on rat livers from three separate studies with triazole treatment groups ranging from 6 h after a single oral gavage exposure, to prenatal to adult exposures via feed.

To explore conservation of responses across species, gene expression from the...

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