lou gehrig

Gene Find Sheds Light On Motor Neuron Diseases Like ALS

admin — Mon, 27 Oct 2008 00:45:12 -0500

Scientists have identified a gene in mice that plays a central role in the proper development of one of the nerve cells that goes bad in amyotrophic lateral sclerosis, or Lou Gehrig's disease, and some other diseases that affect our motor neurons.

Lou Gehrig's Protein Found Throughout Brain, Suggesting Effects ...

admin — Thu, 19 Jun 2008 21:15:12 -0500

Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with Lou Gehrig's disease. Now, the same group has shown that TDP-43 accumulates throughout the brain, suggesting the disease has broader neurological effects than previously appreciated and treatments need to take into account more than motor neuron areas.

Yeast Has Potential For Selecting Lou Gehrig's Disease Drugs, St...

admin — Mon, 21 Apr 2008 20:00:00 -0500

Researchers are developing a novel approach to screen for drugs to combat neurodegenerative diseases such as amyotrophic lateral sclerosis, or Lou Gehrig's disease -- using yeast cells. The clumping process of proteins takes decades in humans but the researchers could model the process within a matter of hours in yeast cells. This now allows for rapid genetic screening to identify proteins that can reverse the harmful effects of the disease protein; visualizing the clumping; and testing molecules that could eliminate or prevent clumping.

Early Clinical Trial Results Back New Drug For Melanoma

admin — Fri, 18 Apr 2008 08:00:00 -0500

Preliminary but encouraging findings from a Phase 0 human clinical trial of a melanoma drug have been reported. Scientists found an approved drug used to treat Lou Gehrig's disease (ALS), slows the growth of melanoma, the most aggressive form of malignant skin cancer.

Chemical Exposure May Increase Risk Of ALS, Study Shows

admin — Thu, 17 Apr 2008 23:00:00 -0500

Preliminary results show that a common environmental chemical may increase the risk of developing amyotrophic lateral sclerosis, also known as Lou Gehrig's disease, according to new research.

Leaky Blood Vessels Open Up Nerve Cells To Toxic Assault In Lou ...

admin — Wed, 09 Apr 2008 11:00:00 -0500

Leaky blood vessels that lose their ability to protect the spinal cord from toxins may play a role in the development of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, according to research in Nature Neuroscience.

More Genes For Lou Gehrig's Disease Identified

admin — Tue, 08 Apr 2008 17:00:00 -0500

In recent months a spate of mutations have been found in a disease protein called TDP-43 that is implicated in two neurodegenerative disorders: amyotrophic lateral sclerosis, also called Lou Gehrig's disease, and certain types of frontotemporal dementia. These mutations could potentially become candidates for drug targets. Recently, scientists have found two more mutations.

New Gene Responsible For Lou Gehrig's Disease Identified

admin — Mon, 31 Mar 2008 17:00:00 -0500

Scientists have identified a novel gene responsible for a significant fraction of ALS (sporadic amyotrophic lateral sclerosis) cases. ALS is commonly referred to as Lou Gehrig's disease, an incurable neuromuscular disorder that affects motor neurons and leads to paralysis and death within one to five years.

Gene Responsible For Lou Gehrig's Disease Identified

admin — Mon, 31 Mar 2008 00:00:00 -0500