cincinnati children

Genetic breakdown in Fanconi anemia may have link to HPV-associa...

admin — Tue, 02 Dec 2008 23:00:00 -0600

(Cincinnati Children's Hospital Medical Center) A genetic malfunction that causes DNA instability in people with the blood disorder Fanconi anemia may put them at high risk for squamous cell carcinomas linked to human papillomavirus, according to a study posted online ahead of print by Oncogene. Researchers led by Cincinnati Children's Hospital Medical Center report breakdown of a cell signaling pathway for the FA gene complex triggers cellular abnormalities, when then are made worse by HPV cancer genes in skin cells.

Children More Vulnerable To Harmful Effects Of Lead

admin — Sun, 04 May 2008 21:15:07 -0500

Contrary to prevailing assumptions, children are more vulnerable to the harmful effects of lead exposure at the age of 6 than they are in early childhood, according to a Cincinnati Children's Hospital Medical Center study.

Potential viral therapy weapon for difficult cancers is safe and...

admin — Tue, 22 Apr 2008 00:00:00 -0500

Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a chemotherapy drug effectively and safely reduced the size of highly malignant human sarcoma grafted into mice. This new finding may add to the growing arsenal of so called oncolytic viruses under development as novel cancer treatments, especially for difficult, inoperable tumors, according to a research led by Cincinnati Children's Hospital Medical Center and published April 24 in Molecular Therapy.

Investigational drug tested for preventing muscle fiber death in...

admin — Sun, 16 Mar 2008 00:00:00 -0500

An investigational antiviral drug currently undergoing human trials in Europe for treating hepatitis C infections may have potential to reduce muscle cell damage in Duchenne and other forms of muscular dystrophy. A research team led by Cincinnati Children's Hospital Medical Center reported their results using three different mouse models of MD in a letter posted online March 16 by the journal Nature Medicine.