Responses of human alveolar machrophages to diesel exhaust expos...

Courtesy Recent Science Inventory records from the EPA  Tue, 11/03/2009 - 12:14

Human exposure studies demonstrate that acute exposure to diesel exhaust (DE) stimulates mild airway inflammation, characterized by the production of inflammatory mediators and neutrophil influx into the airways.

The mechanism(s) by which diesel exposure induces lung inflammation and injury is unclear, but may involve biochemical manipulation of phospholipid metabolic pathways.

The current study employed a lipidomics approach to evaluate the effect of in vivo DE exposure and an in vitro DE particle (DEP) exposure on human alveolar macrophage (AM) phospholipid...

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