One-month diesel exhaust inhalation produces hypertensive gene e...

Courtesy Recent Science Inventory records from the EPA  Tue, 11/17/2009 - 14:17

Background - Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial dysfunction, and myocardial ischemia in compromised individuals.

Objective - We hypothesized that DE inhalation would cause greater inflammation, hematological alterations, and cardiac molecular impairment in spontaneously hypertensive (SH) than healthy Wistar Kyoto (WKY) rats.

Methods and Results - Male rats (12-14 weeks) were exposed to air or DE from a 30 kW Deutz engine at 500 or 2000 ?g/m3, 4h/d, 5 d/week for 4 weeks.

Neutrophilic influx was...


 

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