Leaky, twisted blood vessels in tumors often prevent chemotherapy drugs from reaching their target. Children's Hospital Boston researchers have found that tumor capillary cells, unlike their normal counterparts, are hyper-contractile and respond abnormally to physical and mechanical cues, producing irregularly-shaped capillaries and creating gaps between cells that caused vessel leakiness.
A protein called Rho-associated kinase is the likely culprit; inhibiting its function normalized the tumor cells' mechanical responsiveness, as well as blood vessel architecture.
Normalizing Tumor Vessels To Improve Cancer TherapyCourtesy ScienceDaily Tue, 08/26/2008 - 07:45
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