likelihood function

This works extends the 2-stage cancer modeling of tumor incidence in formaldehyde-exposed rats carried out at the CIIT Centers for Health Research.

We modify key assumptions, evaluate the effect of selected uncertainties, and develop confidence bounds on parameter estimates.

The broad features of our model are similar to the CIIT effort and the related input data were obtained from that work.

Our approach differs from that work due to the following. (1) We develop non-homogeneous solutions to the 2-stage MVK cancer model.

This replaces the homogeneous solutions due to Hoogenveen et al.