clinical trial

In a large clinical trial involving patients with coronary artery disease, use of B vitamins was not effective for preventing death or cardiovascular events, according to a study published in the Aug. 20 issue of JAMA.

Could injecting a gene into a patient with severe heart failure reverse their disabling and life-threatening condition?

Physician-scientists are setting out to answer that question in a first-ever clinical trial of gene therapy to treat severe heart failure.

Clinical trials hoping to identify a vaginal microbicide that is safe and effective against HIV have all but skirted questions befitting evaluation of an approach intended primarily for sexually active women of childbearing age: What if a woman gets pregnant while using a product?

Can exposure during pregnancy pose a risk to the fetus? Researchers will begin addressing these and other questions in the first clinical trial of a candidate vaginal microbicide in pregnant women.

A blood substitute's effectiveness and safety was addressed in a large Phase III clinical trial by academic and industry researchers.

(Microbicide Trials Network) Clinical trials hoping to identify a vaginal microbicide that is safe and effective against HIV have all but skirted questions befitting evaluation of an approach intended primarily for sexually active women of childbearing age: What if a woman gets pregnant while using a product?

Can exposure during pregnancy pose a risk to the fetus? Researchers will begin addressing these and other questions in the first clinical trial of a candidate vaginal microbicide in pregnant women.

By targeting and disabling a protein frequently found in melanoma tumors, doctors may be able to make the cancer more vulnerable to chemotherapy, according to a new study.

Although this study was done in laboratory rats, a clinical trial applying the same concept to humans has already begun at four comprehensive cancer centers nationwide.

Results from a major clinical trial show that adding a screening ultrasound examination to routine mammography reveals more breast cancers than mammography alone -- but also increases the rates of false positive findings.

A simplified economical method of giving rabies vaccine is just as effective as the expensive standard vaccine regimen at stimulating anti-rabies antibodies, study shows.

A clinical trial in healthy volunteers has found that a simpler and cheaper way of using rabies vaccines proved to be just as effective as the current most widely used method at stimulating antibodies against rabies.

Right now, about half of all people who take medicine for an anxiety disorder don't get much help from it. And doctors have no definitive way to predict who will, and who won't, benefit from each antianxiety prescription they write.

But in a recently published study and a new clinical trial, scientists are working to bring more certainty to anxiety treatment, by probing the connection between brain activity, genetics and medication.

Biotechnology companies are increasingly turning to developing nations as sites for clinical trials, reports Genetic Engineering and Biotechnology News.

Increasing competition for clinical trial patients in the industrialized world is one of the major reasons for the offshore move, according to an article in the March 15 issue of GEN.