chemotherapy drugs

Researchers have developed a promising nanomaterial-based biomedical device that could be used to deliver chemotherapy drugs locally to sites where cancerous tumors have been surgically removed.

The team demonstrated that the flexible microfilm device, which resembles a piece of plastic wrap and can be customized easily into different shapes, releases the chemotherapy agent doxorubicin in a sustained and consistent manner.

The device takes advantage of nanodiamonds, an emergent technology.

(Northwestern University) Northwestern University researchers have developed a promising nanomaterial-based biomedical device that could be used to deliver chemotherapy drugs locally to sites where cancerous tumors have been surgically removed.

The team demonstrated that the flexible microfilm device, which resembles a piece of plastic wrap and can be customized easily into different shapes, releases the chemotherapy agent doxorubicin in a sustained and consistent manner.

The device takes advantage of nanodiamonds, an emergent technology.

Leaky, twisted blood vessels in tumors often prevent chemotherapy drugs from reaching their target. Children's Hospital Boston researchers have found that tumor capillary cells, unlike their normal counterparts, are hyper-contractile and respond abnormally to physical and mechanical cues, producing irregularly-shaped capillaries and creating gaps between cells that caused vessel leakiness.

(Children's Hospital Boston) Leaky, twisted blood vessels in tumors often prevent chemotherapy drugs from reaching their target.

Children's Hospital Boston researchers have found that tumor capillary cells, unlike their normal counterparts, are hyper-contractile and respond abnormally to physical and mechanical cues, producing irregularly-shaped capillaries and creating gaps between cells that caused vessel leakiness.

Researchers have created the first 3-D image of how a well-established chemotherapy agent targets and binds to DNA.

These images may help scientists develop better chemotherapy drugs to treat a wide range of cancers.