cell signaling

A new mathematical model gives scientists a smarter way to learn which cellular processes are key in many diseases and thus find the most effective drug targets.

Scientists say the model, now freely available to researchers, should speed the search for effective treatments for cancer, inflammation and other conditions that affect millions of people.

We present a model for the regulation of a conserved diguanyate cyclase from Pseudomonas that is responsible for cyclic di-GMP production and biofilm formation, providing insight into the molecular mechanism controlling cell signaling and virulence.