cell death

Scientists have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex, which is responsible for triggering apoptosis, or programmed cell death.

(Burnham Institute) Scientists at Burnham Institute for Medical Research have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex, which is responsible for triggering apoptosis, or programmed cell death.

Nanoparticles that are one milliard of a meter in size are widely used, for example, in cosmetics and food packaging materials.

There are also significant amounts of nanoparticles in exhaust emissions. New findings give rise to concern that nanoparticles carry potential health hazards.

(Tampere University of Technology) The findings of a recent Finnish-American study give rise to concern that nanoparticles carry potential health hazards.

Scientists have decrypted the molecular mechanism through which the death of cells is caused by oxidative stress.

This knowledge opens novel perspectives to systematically explore the benefit of targeted therapeutic interventions in the cure of aging and stress-related degenerative diseases.

Researchers have found evidence explaining why a common chemotherapy drug, cisplatin, may not always work for every cancer patient.

They have shown that when a variant version of a key protein that normally causes cell death is active, patients may be resistant to the cancer-killing drug.

On the cellular level, death signals can actually be life saving -- by killing off abnormally dividing cells before they turn cancerous.

Now, Rockefeller University researchers have found a way to amplify these signals by turning a life affirming protein into a killer.

The findings not only mark a breakthrough in the field but also open the door to a new line of drugs for cancer therapeutics.

(Rockefeller University) On the cellular level, death signals can actually be life saving -- by killing off abnormally dividing cells before they turn cancerous.

Now, Rockefeller University researchers have found a way to amplify these signals by turning a life affirming protein into a killer.

The findings not only mark a breakthrough in the field but also open the door to a new line of drugs for cancer therapeutics.

Individuals with one of the most aggressive types of brain tumor have an extremely poor prognosis. Although some patients with GBM respond to treatment with drugs known as RTK inhibitors, most subsequently relapse after only a short time.

New data, have now provided insight into the mechanism by which GBM cells become resistant to RTK inhibitors and suggest a way to improve the efficacy of RTK inhibitors as a treatment for GBM.

A study, led by University of Iowa researchers, reveals a new dimension for a key heart enzyme and sheds light on an important biological pathway involved in cell death in heart disease.

The study, published in the May 2 issue of Cell, has implications for understanding, and potentially for diagnosing and treating, heart failure and arrhythmias.