cell based assays

Discusses the EPA/NCCT ToxRefDB database. The EPA is building capacity for multi-dimensional evaluation of toxicity using information aboout chemical properties, genome-wide responses, and cell-based assays.

ToxCast is a research program to predict or forecast toxicity by evaluating a broad spectrum of chemicals and effects; physical-chemical properties, predicted bioactivities, HTS and cell-based assays, and genomics.

Data will be interpretively linked to known or predicted toxicological properties to develop methods for chemical classification and prioritizing subsequent testing.

EPA's National Center for Computational Toxicology is building capabilities to support a new paradigm for toxicity screening and prediction.

The DSSTox project is improving public access to quality structure-annotated chemical toxicity information in less summarized forms than traditionally employed in SAR modeling, and in ways that facilitate data-mining, and data read-across.

Biotech and pharma companies are increasingly relying on cell-based assays in early drug discovery work, reports Genetic Engineering & Biotechnology News.

The technique can provide a quick and lower cost means of testing drug candidates for toxic effects, according to an article in the April 15 issue of GEN.