b cells

Researchers have discovered an important factor in the development of B-cell lymphomas, one of the fastest growing forms of cancer.

The B-cell receptor on the surface of B cells can cooperate with the MYC oncogene to accelerate the development of lymphomas.

The research team also showed that disruption of signals from the B-cell receptor can inhibit growth of the tumors.

B cells, precursors of autoantibody-secreting cells, have emerged as promising new therapeutic targets in autoimmune diseases, including rheumatoid arthritis.

Researchers have uncovered definitive evidence that a small but potent subset of immune system B cells is able to regulate inflammation.

Using a new set of scientific tools to identify and count these cells, the team showed that these B cells can block contact hypersensitivity, the type of skin reactions that many people have when they brush against poison ivy.

Fully differentiated mouse cells, such as mature B cells, can be reprogrammed to embryonic-stem-cell-like induced pluripotent stem cells, without the use of an egg.

Using reprogrammed mature B cells, researchers may be able to create mouse models that will aid in understanding autoimmune diseases such as multiple sclerosis and type 1 diabetes.

Fully differentiated mouse cells, such as mature B cells, can be reprogrammed to embryonic-stem-cell-like induced pluripotent stem cells, without the use of an egg.

Using reprogrammed mature B cells, researchers may be able to create mouse models that will aid in understanding autoimmune diseases such as multiple sclerosis and type 1 diabetes.