animal models

(European Science Foundation) Increased use of computers to create predictive models of human disease is likely following a workshop organized by the European Science Foundation, which urged for a collaborative effort between specialists in the field.

Human disease research produces an enormous amount of data from different sources such as animal models, high throughput genetic screening of human tissue, and in vitro laboratory experiments.

In a disease like ALS -- one that's always fatal and that has a long history of research-resistant biology -- finding a proof of principle in animal models is significant.

This database was developed by assembling and evaluating the literature relevant to human biomarkers. It catalogues and evaluates the usefulness of biomarkers of exposure, susceptibility and effect which may be relevant for a longitudinal cohort study.

In addition to describing currently available, reliable human biomarkers, the report also reviews up-and-coming techniques and biomarkers in animal models that could be tested for application in human studies.

The molecular and biochemical mechanism of action of unique cytokine gene found to induce potent bystander antitumor effects in animal models and in Phase I clinical trials has been identified.

For the first time, a research group has provided an explanation of how eating broccoli might reduce cancer risk based upon studies in men, as opposed to trying to extrapolate from animal models.

Prostate cancer is the most common non-skin cancer for males in western countries. The research has provided an insight into why eating broccoli can help men stay healthy.

Unexpected findings suggest need for alternate therapeutic approaches, different animal models for future research.

One of the characteristics of the brain of people with Alzheimer disease (AD) is the presence of tangles, insoluble twisted fibers that build up inside the nerve cells of the brain resulting in malfunctions in communication between nerves and later in their death.

Researchers are studying possible connections between living in disadvantaged neighborhoods and the development of early onset breast cancer in a path-breaking project that is the first to use animal models to help determine what the biological factors might be behind the development of certain forms of breast cancer.

Neuroscientists studying the mind's ability to process images have completed the first empirical study to demonstrate, using animal models, how populations of nerve cells in visual cortex adapt to changing images.

Their findings could lead to sight-improving therapies for people following trauma or stroke.

Cocaine addicts often suffer a downward emotional spiral that is a key to their craving and chronic relapse. While researchers have developed animal models of the reward of cocaine, they have not been able to model this emotional impact, until now.

Neuroscientists studying the mind’s ability to process images have completed the first empirical study to demonstrate, using animal models, how populations of nerve cells in visual cortex adapt to changing images.

Their findings could lead to sight-improving therapies for people following trauma or stroke.