New Hope For Immunocompromised Individuals With Drug-resistant F...

Courtesy ScienceDaily  Mon, 02/09/2009 - 23:00

Even the most drug-resistant fungi can be eradicated in multiple in vitro and in vivo models using a lethal combination of an antifungal agent and inhibition of a specific heat shock protein (Hsp90).

Such findings could point to a novel approach for the development of future antifungal therapies for patients with compromised immune systems.

Immunocompromised individuals -- including HIV, chemotherapy, and organ transfer patients -- with drug-resistant fungal infections suffer mortality rates ranging from 50 to 90 percent.

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