Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mi...

Courtesy Recent Science Inventory records from the EPA  Tue, 11/25/2008 - 08:28

Perfluorooctanoic acid (PFOA) displays complicated pharmacokinetics in that plasma serum concentration indicates a long half life ? 3.8 years in humans (Olsen et al. 2007) ? but also rapidly achieves steady-state (Lau et al., 2006).

Attempts to address this have included using different pharmacokinetic parameters for different doses (Washburn et al., 2005, Trudel et al., 2008) as well as biologically-based models such as the saturable resorption model of Andersen et al.

(2006). We examined plasma concentration time-courses for female CD1...

Tags:

 

More related items

Pharmacokinetic Modeling of Perfluoroalkyl Acids in...
Perfluorooctanoic acid (PFOA) has pharmacokinetic properties that appear consistent with a number of processes that are currently not well understood. Studies in mice exposed orally at lower...

Celestron Research Microscope
Our finest biological microscope. It uses an adjustable illuminator with an illuminator with an Abbe 1.25 condenser, iris diaphragm, filters, and holder. The built-in mechanical stage is...

Four Laws That Drive the Universe
The laws of thermodynamics drive everything that happens in the universe. From the sudden expansion of a cloud of gas to the cooling of hot metal, and from the unfurling of a leaf to the...


 

Post new comment

The content of this field is kept private and will not be shown publicly.
Popular by tags

Week

  • -- no stats yet --
science-nature.marc8.com