Ketoconazole in the Fathead Minnow Pimephales promelas: Reproduc...

Courtesy Recent Science Inventory records from the EPA  Wed, 11/19/2008 - 15:41

Ketoconazole (KTC) is a model pharmaceutical representing inidazole and triazole pesticides which inhibit fungal growth through blocking a cytochrome P450 (CYP)-mediated step in ergosterol biosynthesis.

Overall, our data indicate that, while KTC adversely affects steroidogenesis and reproduction in the fathead minnow, the fish can compensate to some degree to mitigate some effects of the fungicide.

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