Genetic breakdown in Fanconi anemia may have link to HPV-associa...

(Cincinnati Children's Hospital Medical Center) A genetic malfunction that causes DNA instability in people with the blood disorder Fanconi anemia may put them at high risk for squamous cell carcinomas linked to human papillomavirus, according to a study posted online ahead of print by Oncogene.

Researchers led by Cincinnati Children's Hospital Medical Center report breakdown of a cell signaling pathway for the FA gene complex triggers cellular abnormalities, when then are made worse by HPV cancer genes in skin cells.


 

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