Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) are commonly found as contaminants in complex mixtures in the environment.
Several of these compounds bioaccumulate in the tissues of fish, birds, and mammals and have been shown to cause mortality and adverse effects on reproduction, development, and the immune system.
For more than a decade, EPA and other organizations have estimated the combined risks that such mixtures pose to human health using a method known as the toxicity equivalence methodology....
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