A facile and regioselective synthesis of 1,4-disubstituted 1,2,3...

Courtesy Recent Science Inventory records from the EPA  Wed, 07/15/2009 - 09:28

The reaction of ?-tosyloxy ketones, sodium azide and terminal alkynes in presence of copper(I) in aqueous polyethylene glycol afforded regioselectively 1,4-disubstituted 1,2,3-triazoles in good yield at ambient temperature.

The one-pot exclusive formation of 1,4-disubstituted 1,2,3-triazoles involve in situ formation of ?-azido ketones, followed by cycloaddition reaction with terminal alkyne.

The generality of this one-pot method was demonstrated by synthesizing an array of diverse 1,4-disubstituted 1,2,3-triazoles.

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