Evidence for Compensatory Responses at the Molecular, Biochemica...

Courtesy Recent Science Inventory records from the EPA  Tue, 10/27/2009 - 14:21

In order to survive, organisms require a capacity to adapt to a wide variety of biotic and abiotic stressors, including chemicals of both natural and synthetic origin.

Recent studies in our laboratory have provided evidence of compensatory responses to endocrine active chemicals that act by inhibiting one or more enzymes involved in steroid biosynthesis.

Specifically, we conducted a series of experiments in which fathead minnows were exposed to either the aromatase inhibitor, fadrozole, or the fungicide, ketoconazole, for varying durations...

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