Evaluating the Toxicity Pathways Using High-Throughput Environme...

Courtesy Recent Science Inventory records from the EPA  Tue, 12/29/2009 - 08:35

The application of HTS methods to the characterization of human phenotypic response to environmental chemicals is a largely unexplored area of pharmacogenomics.

The U.S. Environmental Protection Agency (EPA), through its ToxCast program, is developing predictive toxicity approaches that use in vitro high-throughput screening (HTS) to profile and model the bioactivity of environmental chemicals.

Current efforts draw from the extensive use of HTS technologies by pharma and biotech industries for the purposes of drug discovery, with notable similarities and differences.

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