Determination of relative potencies for chemical inhibition of s...

Courtesy Recent Science Inventory records from the EPA  Thu, 07/09/2009 - 12:16

Potency determination is important to identify the most promising drug candidates as well as identification of and ranking of compound toxicity.

In our laboratory, we have utilized MEA recording techniques to determine the relative potency of 11 insecticidal compounds and rank their relative potency.

Primary cultures of rat cortical neurons were grown on glass MEA electrodes for a period of 9-16 days, when steady state spontaneous spiking activity was reached.

Cumulative concentration-response determinations of the inhibition of spontaneous spiking behavior...

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