A Computational Model of the Hypothalamic-Pituitary-Gonadal Axis...

Courtesy Recent Science Inventory records from the EPA  Thu, 11/12/2009 - 14:34

Estrogenic chemicals in the aquatic environment have been shown to cause a variety of reproductive anomalies in fish including full sex reversal, intersex, and altered population sex ratios.

Two estrogens found in the aquatic environment, 17?-ethinylestradiol and 17?-estradiol, have been measured in wastewater treatment effluents and have been shown to cause adverse effects in fish.

To further our understanding of how estrogen exposure affects reproductive endpoints in the male fathead minnow (FHM, Pimephales promelas), a physiologically based computational model was...


 

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